ty -jour a2 -dalmarco，eduardo au -ding，jiameng au -wenjuanyang，au -jiang，yuhui au -ji -ji，jie au -jie au -zhang -jie au -jie au -wu -wu，liwei au，liewei au -liwei au-，Yan au -cheng，Ziqi au -yu，Qiang au -Wu -Wu，Jianye au -li，li，Jingjing au -Chen，Kan au -kan au -guo -guo，chuanyong py -2022 da -2022/2022/07/22通过抑制MAPK/NF-的再灌注损伤κB途径SP -5676256 VL -2022 AB-肝缺血/再灌注损伤（HIRI）是需要肝断开的常见并发症，例如肝切除术和肝移植。这项研究的目的是研究虫草蛋白对HIRI的影响并阐明潜在的机制。将BALB/C小鼠随机分为六组：正常对照组，假手术组，H-Cordycepin组，HIRI组，L-Cordycepin（25 mg/kg）+HIRI组和H-Cordycepin（50 mg/kg） + HIRI group. Mice were subjected to I/R, and cordycepin was intragastrically administered for seven consecutive days before surgery. Orbital blood and liver specimens were collected at 6 and 24 h after HIRI. Serum levels of ALT and AST were decreased in the cordycepin pretreatment groups. Notably, cordycepin attenuated the inflammatory response and the production of proapoptosis proteins, while increasing expression of antiapoptosis proteins and decreasing expression of autophagy-linked proteins. Furthermore, cordycepin inhibited activation of the MAPK/NF- κB信号通路。总的来说，这些结果表明虫草预处理改善了HIRI引起的肝细胞损伤。与HIRI组相比，虫干菌预处理减轻了炎症反应，并通过调节MAPK/NF-- κB信号通路。SN -0962-9351 UR -https：//doi.org/10.1155/2022/5676256 do -10.1155/2022/2022/5676256 JF-炎症pb -hindawi kw -er -er- er- er- er- er- er- er-