TY - A2的阿里•谢赫Md赛义德AU -邓,林盟- Mi,金陵盟——阮,小兰AU -张,国珍AU -潘,Yufei AU - Wang仁生PY - 2022 DA - 2022/10/17 TI -伴随老化基因的识别和分析头颈部鳞状细胞癌的一个全面的生物信息学方法SP - 4007469六世- 2022 AB -头部和颈部癌症是全世界第六最常见癌症,多数亚型的头颈部鳞状细胞癌(HNSCC)。细胞senescence-associated基因已经被确诊癌症中发挥关键作用和有潜力成为癌症的预后标志物。HNSCC样本的临床信息和表达数据从公共数据库中获得。表达谱的基因与细胞衰老相关聚类被用来识别分子亚型共识。筛选差异表达基因(度)不同亚型之间,差异分析。我们使用了单变量Cox回归确定预后度和执行至少绝对收缩和选择算子(套索)优化和构建预测模型。CIBERSORT、估计和潮流工具应用于估计的免疫特性。四分子亚型建立了基于细胞senescence-associated基因。不同亚型之间的差预后观察C4有最长的总体预后生存和C1最差。C4亚型还显示最高的免疫渗透。 We screened a total of eight cellular senescence prognosis-related genes and established a cellular senescence-related signature score (CSRS.Score) that could stratify samples into high-CSRS.Score and low-CSRS.Score groups. The high-CSRS.Score group had worse prognosis, lower immune infiltration, and lower response to immunotherapy. We further improved the prognostic model and survival prediction by combining CSRS.Score with clinicopathological features using a decision tree model, which had high predictive accuracy and survival prediction. This study demonstrated an important role of cellular senescence in HNSCC. The identified eight cellular senescence-associated genes have the potential to provide ideas for adjuvant treatment and personalized treatment of HNSCC patients. SN - 0962-9351 UR - https://doi.org/10.1155/2022/4007469 DO - 10.1155/2022/4007469 JF - Mediators of Inflammation PB - Hindawi KW - ER -