Ty-Jour A2 - Ryffel，Bernard Au - Cancizia Au - Aiello，Anna Au - Accarci，Giulia Au - Caldarella，Rosalia Au - Canorore，Giuseppina Au - Caruso，Calogero Au - Ciaccio，Marcello Au - Cristaldi，Laura Au -DI Gaudio，Francesca Au - Siino，Valentina Au - Vasto，Sonya Py - 2020 da - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 2020/05/05 - 衰老和长寿中的基质金属蛋白酶（MMP-2和MMP-9）的作用：专注于西西里人的长 -生活个体（LLIS）SP-8635158 VL - 2020 AB - 细胞外基质金属蛋白酶（MMP）是一组蛋白质，其通过酶促切割激活底物，并且在其活性的基础上已经证明在老化中发挥作用。因此，为了深入了解老化的病理生理学和鉴定寿命的新标志，我们分析了与各种相关血液化学参数相关联的MMP-2和MMP-9的活动水平，包括长期以来的人（llis，≥95岁）。招募了154个健康受试者（72名男子和82名女性）不同年龄（20-112岁）的队列。队列分为五个亚组：第一个群体的主题不到40岁，第二组从40岁到64岁，第三组从65到89岁，第四组从90到94岁老年人，第五组与95岁以上的受试者。在LLIS和MMP-2之间观察到一种关系，但在LLI和MMP-9之间。但是，在LLI组中，MMP-2和MMP-9值显着相关。 Furthermore, in LLIs, we found a positive correlation of MMP-2 with the antioxidant catabolite uric acid and a negative correlation with the inflammatory marker C-reactive protein. Finally, in LLIs MMP-9 values correlated directly both with cholesterol and with low-density lipoproteins. On the whole, our data suggest that the observed increase of MMP-2 in LLIs might play a positive role in the attainment of longevity. This is the first study that shows that serum activity of MMP-2 is increased in LLIs as compared to younger subjects. As far as we are concerned, it is difficult to make wide-ranging conclusions/assumptions based on these observations in view of the relatively small sample size of LLIs. However, this is an important starting point. Larger-scale future studies will be required to clarify these findings including the link with other systemic inflammatory and antioxidant markers. SN - 0962-9351 UR - https://doi.org/10.1155/2020/8635158 DO - 10.1155/2020/8635158 JF - Mediators of Inflammation PB - Hindawi KW - ER -