ty -jour a2-钢，海伦·C·艾（Helen C）巨噬细胞发炎会恶化与年龄有关的疾病SP -4260309 VL -2019 AB-衰老和与年龄有关的疾病（ARDS）共享基本机制，主要涉及炎症。慢性，低度，亚临床炎症称为炎症。Autophagy defects, oxidative stresses, senescence-associated secretory phenotypes (SASPs), and DNA damage generally contribute to inflammaging and are largely regulated by numerous lncRNA through two-level vicious cycles disrupting cellular homeostasis: (1) inflammaging and the cellular senescence cascade and (2）自噬缺陷，氧化应激和SASP级联反应。SASP和炎症体同时引起炎症。这篇综述讨论了巨噬细胞炎症在各种ARD中的参与及其通过LNCRNA的调节。在巨噬细胞中，这种现象可能会损害其免疫监视和吞噬作用机制，从而导致识别和清除恶性和衰老细胞的识别降低。此外，SASP的细胞外表现会诱导旁分泌衰老。巨噬细胞衰老会升级为器官水平故障，并且该生物更容易出现ARDS。通过靶向基因和蛋白质或作为竞争性内源性RNA（CERNA）发挥作用，lncRNA调节了包括炎症和ARD的不同现象。 The detailed mechanism warrants further elucidation to obtain pathological evidence of ARDs and potential treatment approaches. SN - 0962-9351 UR - https://doi.org/10.1155/2019/4260309 DO - 10.1155/2019/4260309 JF - Mediators of Inflammation PB - Hindawi KW - ER -