TY -的A2 Alessenko爱丽丝AU -海特,Nitai c . AU - Maiti阿帕纳PY - 2017 DA - 2017/11/15 TI - Sphingosine-1-Phosphate的作用,在炎症和癌症Ceramide-1-Phosphate SP - 4806541六世- 2017 AB -炎症是我们身体的一部分对组织损伤和病原体的反应。它帮助招募各种免疫细胞的炎症和激活介质的生产动员系统性保护过程。然而,慢性炎症可以增加癌症等疾病的风险。除了细胞因子和趋化因子,脂质介质,尤其是sphingosine-1-phosphate (S1P)和ceramide-1-phosphate (C1P),导致炎症和癌症。S1P在炎症反应结肠癌进展是一个重要的角色。另一方面,C1P已经承认参与癌症细胞生长、迁移、生存和炎症。然而,C1P是否参与炎症反应癌症还没有建立。相比之下,一些研究也表明,S1P和C1P参与抗炎通路调节在某些细胞类型。神经酰胺是神经酰胺激酶的底物(CERK)收益率C1P,和鞘氨醇是由鞘氨醇激酶磷酸化对S1P (SphKs)。鞘脂类代谢产物的生物功能已被广泛的研究。 Ceramide is associated with cell growth inhibition and enhancement of apoptosis while S1P and C1P are associated with enhancement of cell growth and survival. Altogether, S1P and C1P are important regulators of ceramide level and cell fate. This review focuses on S1P and C1P involvement in inflammation and cancer with emphasis on recent progress in the field. SN - 0962-9351 UR - https://doi.org/10.1155/2017/4806541 DO - 10.1155/2017/4806541 JF - Mediators of Inflammation PB - Hindawi KW - ER -