TY - JOUR A2 - Amedei, Amedeo AU - Wang, Zhi-Yong AU - Zhang, Jun-Ai AU - Wu, Xian-Jin AU - Liang, Yan-Fang AU - Lu, Yuan-Bin AU - Gao, Yu-Chi AU - Dai, You-Chao AU - Yu, Shi-Yan AU - Jia, Yan AU - Fu, Xiao-Xia AU - Rao, Xiaoquan AU - Xu, Jun-Fa AU - Zhong, Jixin PY - 2016 DA - 2016/02/23 TI - IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin SP - 8026494 VL - 2016 AB - Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth.IL-6/STAT3轴激活与各种癌症的药理学和低预测相关联,包括直肠癌,并因此成为潜在的癌症治疗免疫代谢目标并增强化疗抑制肿瘤生长效果研究的目的是调查IL-6抑制法对carboplatin抗脉冲效果的影响IL-6增强表达方式和STAT3激活方式与正常染色组织相比在人体染色体样本中观察到,低级染色体高IL-6STAT3carboplatin(CBP)依赖剂量增加IL-6生成和STAT3激活人体直白LOVO细胞阻塞IL-6中和抗体增强LoVo细胞对carboplatin的化疗敏度IL-6禁止carbolatin诱发STAT3激活IL-6阻塞和carboplatin协同减少循环D1表达式并增强LoVo细胞caspase-3活动测试结果显示抑制IL-6可能提高结肠癌的化疗敏度,高活性STAT3对白金代理SN-0962-9351UR-https://doi.org/101155/8026494DO-10.1155/2016/8026494JF-InflamationPB-Hindawi出版公司KW-ER-