TY -的A2 -德里拉,法比奥·桑托斯AU - Chen渊源AU -罗,Guangyan盟——元,渊源盟——杨娇AU - Wang Xiaoqiong AU -王,小云AU -李,独到的非盟- Liu Zhiguang盟——钟,南山PY - 2014 DA - 2014/09/01 TI -维生素C减轻氧化应激在严重肺炎和肿瘤坏死因子-α和LPS-Induced巨噬细胞SP - 426740六世- 2014 AB -氧化应激是一个重要的外国病原体宿主先天免疫反应的一部分。然而,维生素C对氧化应激和炎症的影响尚不清楚在社区获得性肺炎(CAP)。我们旨在确定维生素C对氧化应激和炎症的影响。帽患者登记。活性氧(ROS)、DNA损伤、超氧化物歧化酶(SOD)活性,肿瘤坏死因子-α(TNF-α)和il - 6在限制病人和LPS-stimulated巨噬细胞细胞分析。与RFP-LC3 MH-S细胞转染质粒。在LPS-stimulated巨噬细胞细胞自噬测量。严重限制病人显示显著增加活性氧、DNA损伤,TNF-α,il - 6。SOD明显降低严重帽。维生素C显著减少ROS, DNA损伤,TNF-α,il - 6。维生素C抑制LPS-induced ROS、DNA损伤TNF-α,il - 6, p38巨噬细胞细胞。 Vitamin C inhibited autophagy in LPS-induced macrophages cells. These findings indicated that severe CAP exhibited significantly increased oxidative stress, DNA damage, and proinflammatory mediator. Vitamin C mitigated oxidative stress and proinflammatory mediator suggesting a possible mechanism for vitamin C in severe CAP. SN - 0962-9351 UR - https://doi.org/10.1155/2014/426740 DO - 10.1155/2014/426740 JF - Mediators of Inflammation PB - Hindawi Publishing Corporation KW - ER -