TY - Jour A2 - McCafferty，Donna-Marie Au - Rodríguez-Gallego，Esther Au - Riera-Borrull，Marta Au - Hernández-Aguilera，Anna Au - Mariné-Casadó，Roger Au - Rull，Anna Au - Beltrán-debón，raúlAu - Luciano-Mateo，Fedra Au - Menendez，Javier A. Au - Vazquez-Martin，Alejandro Au - Sirvent，Juan J. Au - Martín-Paredero，Vicente Au - Corbí，天使L. Au - Sierra-Filardi，Elena Au- Aragonès, Gerard AU - García-Heredia, Anabel AU - Camps, Jordi AU - Alonso-Villaverde, Carlos AU - Joven, Jorge PY - 2013 DA - 2013/12/15 TI - Ubiquitous Transgenic Overexpression of C-C Chemokine Ligand 2: A Model to Assess the Combined Effect of High Energy Intake and Continuous Low-Grade Inflammation SP - 953841 VL - 2013 AB - Excessive energy management leads to low-grade, chronic inflammation, which is a significant factor predicting noncommunicable diseases. In turn, inflammation, oxidation, and metabolism are associated with the course of these diseases; mitochondrial dysfunction seems to be at the crossroads of mutual relationships. The migration of immune cells during inflammation is governed by the interaction between chemokines and chemokine receptors. Chemokines, especially C-C-chemokine ligand 2 (CCL2), have a variety of additional functions that are involved in the maintenance of normal metabolism. It is our hypothesis that a ubiquitous and continuous secretion of CCL2 may represent an animal model of low-grade chronic inflammation that, in the presence of an energy surplus, could help to ascertain the afore-mentioned relationships and/or to search for specific therapeutic approaches. Here, we present preliminary data on a mouse model created by using targeted gene knock-in technology to integrate an additional copy of the CCl2 gene in the Gt(ROSA)26Sor locus of the mouse genome via homologous recombination in embryonic stem cells. Short-term dietary manipulations were assessed and the findings include metabolic disturbances, premature death, and the manipulation of macrophage plasticity and autophagy. These results raise a number of mechanistic questions for future study. SN - 0962-9351 UR - https://doi.org/10.1155/2013/953841 DO - 10.1155/2013/953841 JF - Mediators of Inflammation PB - Hindawi Publishing Corporation KW - ER -