TY -的A2 -林,Chiou-Feng盟——Draijer克里斯蒂娜AU - Robbe,帕特丽夏盟,Boorsma Carian e . AU - Hylkema经济分析家n . AU - Melgert barbroandreasson n . PY - 2013 DA - 2013/02/27 TI -描述三种小鼠模型的巨噬细胞表型House-Dust-Mite-Induced哮喘SP - 632049六世- 2013 AB -哮喘,先天免疫的重要作用越来越被认可。关键的先天免疫细胞在肺巨噬细胞。根据他们收到的信号,巨噬细胞至少可以有M1, M2,或者M2-like表型。这些巨噬细胞表型的行为不知道关于()的严重哮喘。我们有量化的表型在三个模型屋尘螨(HDM)诱导哮喘(14、21和24天)。M1、M2和M2-like表型被确定干扰素调节因子5 (IRF5) YM1,分别和il - 10。我们发现高嗜酸性粒细胞的百分比HDM-exposed老鼠相比,控制但没有HDM模型之间的差异。HDM曝光后T细胞数量高,最高的24-day HDM协议。HDM后M2巨噬细胞的数量与高嗜酸性粒细胞数。在老鼠那么严重哮喘、M1与M2巨噬细胞人数越来越负相关巨噬细胞数。 Lower numbers of M2-like macrophages were found after HDM exposure and these correlated negatively with M2 macrophages. The balance between macrophage phenotypes changes as the severity of allergic airway inflammation increases. Influencing this imbalanced relationship could be a novel approach to treat asthma. SN - 0962-9351 UR - https://doi.org/10.1155/2013/632049 DO - 10.1155/2013/632049 JF - Mediators of Inflammation PB - Hindawi Publishing Corporation KW - ER -