TY-JOURA2-MacciT.M.AU-Hodkinson,BridgetAU-Meyer,Pieter WA.AU - Musenge, Eustasius AU - Tikly, Mohammed AU - Anderson, Ronald PY - 2013 DA - 2013/04/07 TI - Serum Matrix Metalloproteinase-3 in Comparison with Acute Phase Proteins as a Marker of Disease Activity and Radiographic Damage in Early Rheumatoid Arthritis SP - 183653 VL - 2013 AB - Matrix metalloproteinase-3 (MMP-3) is involved in the immunopathogenesis of rheumatoid arthritis (RA), but little is known about its relationship to genetic susceptibility and biomarkers of disease activity, especially acute phase reactants in early RA.MMP-3由ELISA用128个疾病调控和药性病人血清样本测量,并分析共享偶发基因型、一系列循环化学/细胞素、急相应器、自适应机体、软骨蛋白质和简化疾病活动索引MMP-3提升大于1.86纳克/毫升56.25%的病人 P级 < 0 . 万一 数个生物标志相关联,特别是IL-8、IL-6和IFN 南锥体 VEGF和COMP R 值=0.22-0.33 P级 < 0.014 -0.0001和CPR和SAA级别 R = 0.40 0.41重写 P级 < 万元 和SDAI R = 0.29 , P级 < 0.0001 但不随降压或点头性硬化然而,CRP和SAI与SDAI相关联强(对应值0.63和0.54) P级 < 0.001 并发)Comp与吸烟、RF和MMP3相关MMP-3与疾病活动、煽动性调试器和软骨分解大相联,使其成为潜在的疾病严重性生物标志器,但似乎不如CRP和SAA作为早期RA疾病活动生物标志器有用SN-0962-9351UR-https://doi.org/101155/2013/183653DO-10.1155/2013/183653JF-InflamationPB-Hindawi出版公司KW-ER-