TY-JOURA2-ChristofordiAU - Imtiaz Nawaz, Mohd AU - Kangave, Dustan AU - Siddiquei, Mohammed Mairaj AU - Geboes, Karel PY - 2012 DA - 2012/09/29 TI - Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders SP - 493043 VL - 2012 AB - The aim of this study was to determine the levels of the angiogenic and fibrogenic factors osteopontin (OPN), high-mobility group box-1 (HMGB1), and connective tissue growth factor (CTGF) and the antiangiogenic and antifibrogenic pigment epithelium-derived factor (PEDF) in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR), and rhegmatogenous retinal detachment with no PVR (RD).48PDR、17PVR和30RD病人的微量样本由酶关联免疫感应测试研究OPN、HMGB1、CTGF和PEDF比RD病人高得多 P级 < 0.001 脱机0.0020.0010.001重写)CTGF和PEDF水平在PVR病人比RD病人高得多 P级 < 0.001 ; .004 公元前/后/后/后/后/后/后/探索性后勤回归分析发现PDR与HMGB1高水平HMGBB1高水平HMGBB1高水平HMGBBPEDF层次与OPN层次有显著关联 R = 0.544 , P级 = 0.001 HMGB1 R = 0.719 , P级 < 0.001 )和CCTGF R = 0.715 , P级 < 0.001 )光机患者中OPN水平与HMGB1水平有显著关联 R = 0.484 , P级 = 0.049 PEDF系统 R = 0.559 , P级 = 0.02 )发现OPN、HMGB1和CTGF帮助推导增生电素紊乱,提高PEDF水平可能是对PDR和PVR活性抗衡反应SN-0962-9351UR-https://doi.org/101155/2012/493043DO-10.1155/2012/493043JF-InflamationPB-Hindawi出版公司KW-ER-