TY -的A2 Abdel-Daim Mohamed m . AU - Asiedu-Gyekye i . j . AU - Borovskaya t . g . AU - Poluektova m . e . AU - VychuzhaninaА。诉盟——ShchemerovаyА。盟,Kamalova s i盟——Grgoreva诉答:非盟- Amoateng, p . AU - Kukuia k . e . AU - Kwapong a . a . AU - Allotey宾顿,l . AU - Amponsah s . k . AU - N 'guessan比比PY - 2021 DA - 2021/01/13 TI -生殖毒性Theobroma可可:增加生存指数,Nongenotoxic Proimplantation潜在SP - 6114672六世- 2021 AB -不加糖的天然可可(UNCP)在大鼠生殖毒性评价。初步基因毒性可能被评估使用C57Bl / 6小鼠DNA彗星试验测试。治疗剂量(TD;900毫克/公斤)和高剂量(高清;9000毫克/公斤)UNCP。白色Wistar鼠被用于两个实验小组。雌性收到UNCP 15天前与未经治疗的男性。雄性收到UNCP 48天前与未经处理的雌性交配。亚急性毒性观察14天期间UNCP口服。观察结果表明,高尾部DNA百分比与甲磺酸甲酯政府在所有组织进行了分析。 The lowest tail DNA% value was observed in the liver (1.64 ± 0.26) and kidney (1.63 ± 0.30) during UNCP (TD) administration. UNCP did not induce observable physical congenital malformations on the pubs of treated female and male rats, lacks genotoxic potential, and did not adversely affect pregnancy index, pub weights, and survival index, but UNCP exhibited proimplantation potential ( p > 0.05 )。SN - 1687 - 8191 UR - https://doi.org/10.1155/2021/6114672 - 10.1155 / 2021/6114672摩根富林明毒理学杂志PB - Hindawi KW - ER