TY - JOUR A2 - Hseu, You-Cheng AU - Ali, Md. Yousuf AU - Rumpa, Nur-E Noushin AU - Paul, Sudip AU - Hossen, Md. Sakib AU - Tanvir, E. M. AU - Hossan, Tareq AU - Saha, Moumoni AU - Alam, Nadia AU - Karim, Nurul AU - Khalil, Md. Ibrahim AU - Gan, Siew Hua PY - 2019 DA - 2019/06/10 TI - Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (沙田柚L.脐橙）在Long埃文大鼠SP - 2529569 VL - 2019 AB - 本研究的目的是调查抗氧化剂电位，亚急性毒性，和柚的甲醇提取物的受益人效果（ 沙田柚L.脐橙）的影响。Long Evans大鼠随机分为四组，每组8只动物。The rats were orally treated with three doses of pomelo (250, 500, and 1000 mg/kg) once daily for 21 days. Pomelo extract contained high concentrations of polyphenols, flavonoids, and ascorbic acid while exhibiting high 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and ferric reducing antioxidant power values. There was no significant change in the body weight, percentage water content, and relative organ weight at any administered doses. In addition, no significant alterations in the hematological parameters were also observed. However, rats which received 1000 mg/kg dose had a significant reduction in some serum parameters, including alanine transaminase (15.29%), alkaline phosphatase (2.5%), lactate dehydrogenase (15.5%), γ-glutamyltransferase（20％），肌酐（14.47％），尿素（18.50％），尿酸（27.14％），总胆固醇（5.78％），甘油三酯（21.44％），低密度脂蛋白胆固醇（40.74％），葡萄糖(2.48%), and all atherogenic indices including cardiac risk ratio (24.30%), Castelli’s risk index-2 (45.71%), atherogenic coefficient (42%), and atherogenic index of plasma (25%) compared to control. In addition, the highest dose (1000 mg/kg) caused a significant increase in iron (12.07%) and high-density lipoprotein cholesterol (8.87%) levels. Histopathological findings of the vital organs did not indicate any pathological changes indicating that pomelo is nontoxic, safe, and serves as an important source of natural antioxidants. In addition, the fruit extract has the potential to ameliorate hepato- and nephrotoxicities and cardiovascular diseases as well as iron deficiency anemia. SN - 1687-8191 UR - https://doi.org/10.1155/2019/2529569 DO - 10.1155/2019/2529569 JF - Journal of Toxicology PB - Hindawi KW - ER -