TY - Jour A2 - 塞曼诺亚·奥尔龙奥氏 - 加布里，JoséAntonioAu - Rueda，Maríguez，卡罗尔Anahelka Au - Canales，Maritza Au - Sanchez，Ana Lourdes Py - 2016 DA - 2016/11/01 TI -洪都拉斯小学生的免疫剖面与肠道寄生虫：对Geohelminths的偏斜反应SP - 1769585 VL - 2016 - 土壤传播的蠕虫感染通常诱导2型免疫应答（Th2），但在洪都拉斯没有进行免疫遗传学研究endemic country where the main control strategy is children’s annual deworming. We aimed to characterize the immune profile of Honduran schoolchildren harbouring these parasitoses. Demographic and epidemiological data were obtained through a survey; nutritional status was assessed through anthropometry; intestinal parasites were diagnosed by formol-ether and Kato-Katz; and blood samples were collected to determine immunological markers including Th1/Th2 cytokines, IgE, and eosinophil levels. A total of 225 children participated in the study, all of whom had received deworming during the national campaign five months prior to the study. Trichuriasis and ascariasis prevalence were 22.2% and 20.4%, respectively. Stunting was associated with both age and trichuriasis, whereas ascariasis was associated with sex and household conditions. Helminth infections were strongly associated with eosinophilia and hyper-IgE as well as with a Th2-polarized response (increased levels of IL-13, IL-10, and IL4/IFN- γ. 差值和IFN的级别下降 γ. ）。致病性原生动物感染与TH1响应有关，其特征在于IFN的升高 γ. 并减少IL10 / IFN- γ. 比率。即使在低流行水平下，STH感染也会影响儿童的营养，并在免疫系统中发挥偏振作用。SN - 2090-0023 UR - HTTPS://DOI.ORG/10.1155/2016/1769585 DO - 10.1155/2016/1769585 DO - 10.1155/2016/1769585 JF - 寄生学研究杂志PB - Hindwi Publishing Corporation KW - ER -