TY -的A2 -费舍尔,戈登AU -科尔曼,Kristine AU -罗伯逊,尼古拉·d . AU -麦尔Adriane AU - Bethea,辛西娅·l . PY - 2018 DA - 2018/09/27 TI -立即或延迟雌二醇对行为的影响在旧更年期猕猴肥饮食SP - 1810275六世- 2018 AB -猕猴作为有效的人类疾病模型,包括与肥胖和代谢综合征相关的病理过程。这项研究探讨了几个问题:(1)西式饮食(WSD)是否导致了久坐行为，还是久坐行为是肥胖的结果?(2)雌二醇(E)激素疗法是否抵消了WSD或改善了久坐行为?我们进一步质疑E给药的时间(子宫切除术后立即输精管输精管;或者延迟2年后，DE)会影响行为。在开始WSD和子宫切除术之前和之后的两年半时间里，对社会住房中的动物进行了集中观察。此外，焦虑通过人类入侵者测试和新奇物体测试进行评估。所有动物的体重都增加了，但ImE将时间推迟到18个月时达到最大体重。在研究过程中，与安慰剂对照组相比，ime治疗组的猴子有更多的“独处”时间，更少的“亲密社交”时间。在这两种结果上，接受de治疗的猴子与安慰剂对照组没有什么不同。 The placebo-control group exhibited more “self-groom” behavior, an indicator of anxiety, than did the ImE-treated group, and DE-treated animals approached levels observed in the ImE-treated animals. All animals exhibited an increase in “consume” behavior over time with no statistical difference between the groups. By the end of the protocol, the placebo-control group exhibited less activity compared to ImE + DE-treated animals combined. Animals also showed increased anxiety after starting on the WSD in the Human Intruder Test and the Novel Object Test. In summary, the data indicated that WSD per se promoted increased consummatory behavior, sedentary behavior, and anxiety-type behaviors, whereas ImE promoted activity. Thus, WSD may precipitate the behaviors observed in humans who then become obese, sedentary, anxious, and socially isolated. ImE replacement ameliorates some of these behaviors, but not all. SN - 2090-0708 UR - https://doi.org/10.1155/2018/1810275 DO - 10.1155/2018/1810275 JF - Journal of Obesity PB - Hindawi KW - ER -