TY - JOUR A2 - Chen, Yun-dai AU - Zhang, Haichao AU - Qu, Xin AU - Han, Lu AU - Di, Xu PY - 2021 DA - 2021/09/14 TI - Mst2 Overexpression Inhibits Thyroid Carcinoma Growth and Metastasis by Disrupting Mitochondrial Fitness and Endoplasmic Reticulum Homeostasis SP - 1262291 VL - 2021 AB - Although the incidence of thyroid carcinoma has increased over the past several decades, it has an excellent prognosis and overall 5-year survival, with a stable mortality rate, except in cases with advanced stages or rare malignant tumor types.生物标志因快速方便检测而成为分子治疗甲状腺癌的有效目标然而,临床应用微乎其微mst2宏图刺激二类蛋白质对致癌和转移有影响高表情驱动内分片内分片压力MDA-T32甲状腺癌细胞Mist2过份表达作用也促成了线粒体损伤,一如线粒体氧化应激增强所证明的那样,并激活线粒体反渗透路径禁止JNK路径废除这些特效mst2新式肿瘤抑制器 通过JNK路径诱导线粒体机能失常mst2可发挥生物标志作用开发甲状腺癌定向治疗SN-1687-8450UR-https://doi.org/101155/202112291DO-101155/20212691JF-Ocistic PB杂志HindawiKW-ER