TY -的A2 Buyukhatipoglu哈坎AU - Shaik,显得优雅Purusottapatnam盟——Alanazi易卜拉欣o . AU - Pathan,阿里阿克巴汗盟——Parine Narasimha Reddy盟——Almadi Majid a . AU -阿赞Nahla a . AU - Aljebreen阿m . AU - Alharbi Othman AU - Alanazi,默罕默德·沙特盟——汗,Zahid PY - 2020 DA - 2020/03/09 TI -频繁Notch信号通路的激活结肠直肠癌病人及其含义生存结果SP - 6768942六世- 2020 AB -结肠直肠癌是一个主要的健康问题在发病率排名第三和第二全世界癌症相关死亡的主要原因。治疗失败的主要原因归咎于癌症干细胞,可以总是抵抗现有的化疗方案。Notch信号通路参与了干细胞的维持除了细胞命运决定,胚胎发育的关键。这个途径还牵涉到一些人类恶性肿瘤包括结直肠癌。我们调查的mRNA表达四个级距受体(Notch1-4), 5个配体(Jag1, Jag2, Dll1、Dll3 Dll4),和四个目标基因(Hes1, Hes5、Hey1 Hey2)使用高度特定TaqMan基因表达分析在结直肠腺瘤和癌症。调节切口受体的表达范围29 - 73%在结肠直肠癌和腺瘤11至56%。Notch3和新的高度受体的表达明显高于正常和腺瘤组织相比,结肠直肠癌。锯齿状和Delta-like配体在直肠癌中25 - 52%,而在腺瘤,它介于0和33%之间。结合upregulation受体和配体的数据表明,86%的结肠直肠癌和56%的腺瘤表现出过度的Notch通路基因在我们的队列。切口目标基因调节24 - 33%在结肠直肠癌和腺瘤11 - 22%。 Collating upregulation of Notch receptors and ligands with the target genes showed concordance in 58% colorectal tumors. Additionally, we evaluated expression of Notch receptors, ligands, and target genes with prognosis using the TCGA mRNA expression dataset. Patients overexpressing Notch3, Notch4, and Hey1 had significantly poorer overall survival relative to those having lower levels of these genes. Taken together, Notch signaling components are aberrantly overexpressed in colorectal tumors, and development of therapeutics targeting the Notch pathway may prove to be beneficial in the management of colorectal cancers. SN - 1687-8450 UR - https://doi.org/10.1155/2020/6768942 DO - 10.1155/2020/6768942 JF - Journal of Oncology PB - Hindawi KW - ER -