TY -的A2 -【Yawara盟——Ziouti范尼AU -苏亚雷斯,安娜AU - Moreno-Jimenez睡午觉,非盟,齿条,亚历山大AU -弧状,Bjarne盟——Cipitria基本上非盟- Zaslansky保罗盟——Jundt Franziska PY - 2020 DA - 2020/06/27 TI -早期骨髓瘤骨病模型只是成熟小鼠作为细胞外基质的生物材料表征平台SP - 3985315六世- 2020 AB -多发性骨髓瘤(MM)骨髓疾病的特点是溶骨的骨组织破坏导致骨痛、骨折、椎崩溃,和脊髓压迫的病人。在最初诊断毫米,几乎80%的病人患有骨疾病。早期诊断和干预毫米骨病可能提高治疗效果和患者的生存。新的临床前模型需要开发新的诊断标志物的骨骼结构变化尽可能早的疾病。在这里,我们报告一个概念验证,同系的,intrafemoral MOPC315。BM MM小鼠模型只是成熟的BALB / c小鼠早期变化的检测和表征MM-injected动物的细胞外基质(ECM)。生物荧光成像(BLI)体内证实骨髓瘤移植与高100%的动物肿瘤细胞接种后21天内破骨细胞活动。积极的早期迹象骨营业额被高分辨率观察外骨表面microcomputed断层扫描(microCT)。同步加速器相影像微型计算机断层扫描(PCE-CT)显示本地微体系结构差异突出许多活跃的站点的侵蚀和新骨千分尺规模。相关的背散射电子成像(BSE)和共焦激光扫描显微镜可以直接比较的矿化和nonmineralized矩阵皮质骨的变化。 The osteocyte lacunar-canalicular network (OLCN) architecture was disorganized, and irregular-shaped osteocyte lacunae were observed in MM-injected bones after 21 days. Our model provides a potential platform to further evaluate pathological MM bone lesion development at the micro- and ultrastructural levels. These promising results make it possible to combine material science and pharmacological investigations that may improve early detection and treatment of MM bone disease. SN - 1687-8450 UR - https://doi.org/10.1155/2020/3985315 DO - 10.1155/2020/3985315 JF - Journal of Oncology PB - Hindawi KW - ER -