TY -的A2 Yoshiyama Hironori AU - Chan Chee凯盟——Aimagambetova Gulzhanat盟——Ukybassova Talshyn盟——Kongrtay Kuralay盟——Azizan Azliyati PY - 2019 DA - 2019/10/10 TI -人类乳头状瘤病毒感染与宫颈癌:流行病学、筛选和Vaccination-Review当前视角SP - 3257939六世- 2019 AB -病毒感染造成的原因所有人类癌症的15 - 20%。致癌病毒感染可促进不同阶段的癌变。在许多类型的人乳头瘤病毒中，大约有15种与癌症有关。尽管有有效的筛查方法，子宫颈癌仍然是一个重大的公共卫生问题。宫颈癌的发病率和死亡率因地域而有很大差异。此外，不同人群中不同年龄的人乳头瘤病毒流行率差异很大，在年轻和年长女性中出现了两个HPV阳性高峰。由于人类乳头瘤病毒基因型不同，国内外对其感染的流行病学和致癌特性进行了大量研究。然而，仍有许多国家尚未确定以人口为基础的流行率。此外，不同国家的宫颈癌筛查策略也有所不同。有组织的子宫颈筛查项目可能比机会性筛查项目更有效。 Nevertheless, screening programs have consistently been associated with a reduction in cervical cancer incidence and mortality. Developed countries have achieved such reduced incidence and mortality from cervical cancer over the past 40 years. This is largely due to the implementation of organized cytological screening and vaccination programs. HPV vaccines are very effective at preventing infection and diseases related to the vaccine-specific genotypes in women with no evidence of past or current HPV infection. In spite of the successful implementation of the HPV vaccination program in many countries all over the world, problems related to HPV prevention and treatment of the related diseases will continue to persist in developing and underdeveloped countries. SN - 1687-8450 UR - https://doi.org/10.1155/2019/3257939 DO - 10.1155/2019/3257939 JF - Journal of Oncology PB - Hindawi KW - ER -