评论文章
遗传和临床特征的多发性内分泌瘤类型1和2
表4
不同的流行的生殖系遗传变异矿渣MTC在不同的欧洲国家。
|
| RET基因突变 |
意大利()[14] |
德国()[15] |
Euromen ()[16] |
|
| Cys634 |
86例(34.9%) |
57 (40%) |
98例(67.6%) |
| Val804 |
52 (21.1%) |
9 (6.4%) |
3 (2.1%) |
| Ser891 |
23 (9.3%) |
3 (2.2%) |
3 (2.1%) |
| Met918 |
20 (8.1%) |
21 (15%) |
4 (2.8%) |
| Cys618 |
15 (6.0%) |
7 (5%) |
10 (6.9%) |
| Glu768 |
9 (3.6%) |
2 (1.4%) |
1 (0.8%) |
| Cys620 |
9 (3.6%) |
10 (7%) |
10 (6.9%) |
| Leu790 |
8 (3.2%) |
17 (12%) |
7 (4.8%) |
| Cys609 |
6 (2.4%) |
1 (0.7%) |
1 (0.8%) |
| Cys630 |
4 (1.6%) |
1 (0.7%) |
1 (0.8%) |
| Cys611 |
1 (0.4%) |
2 (1.4%) |
4 (2.8%) |
| Tyr791 |
1 (0.4%) |
10 (7%) |
3 (2.1%) |
| Ala883 |
1 (0.4%) |
0 |
0 |
| Cys515 |
1 (0.4%) |
0 |
0 |
| Lys666 |
1 (0.4%) |
0 |
0 |
| Met848 |
1 (0.4%) |
0 |
0 |
| Ser904 |
1 (0.4%) |
0 |
0 |
| Thr338 |
1 (0.4%) |
0 |
0 |
| Asp631 |
0 |
1 (0.7%) |
0 |
| 没有突变 |
6 (2.4%) |
0 |
0 |
|
|
