TY - JOUR A2 - Longatto-Filho, Adhemar AU - Guzmán-Olea, E. AU - Bermúdez-Morales, V. H. AU - Peralta-Zaragoza, O. AU - Torres-Poveda, K. AU - Madrid-Marina, V. PY - 2012 DA - 2011/12/19 TI - Molecular Mechanism and Potential Targets for Blocking HPV-Induced Lesion Development SP - 278312 VL - 2012 AB - Persistent infection with high-risk HPV is the etiologic agent associated with the development of cervical cancer (CC) development. However, environmental, social, epidemiological, genetic, and host factors may have a joint influence on the risk of disease progression. Cervical lesions caused by HPV infection can be removed naturally by the host immune response and only a small percentage may progress to cancer; thus, the immune response is essential for the control of precursor lesions and CC. We present a review of recent research on the molecular mechanisms that allow HPV-infected cells to evade immune surveillance and potential targets of molecular therapy to inhibit tumor immune escape. SN - 1687-8450 UR - https://doi.org/10.1155/2012/278312 DO - 10.1155/2012/278312 JF - Journal of Oncology PB - Hindawi Publishing Corporation KW - ER -