TY -的A2张Xue-Li盟——Lachota Mieszko盟——Lennikov安东盟——只是,Karl-Johan盟——Zagozdzon Radoslaw PY - 2021 DA - 2021/06/12 TI -生物信息学分析显示核心作用在葡萄膜黑色素瘤肿瘤浸润免疫细胞SP - 9920234六世- 2021 AB -肿瘤浸润进展癌症免疫细胞能有效监测,及其丰度在很多肿瘤类型与预后更好。然而,在葡萄膜黑色素瘤(嗯),广泛的免疫渗透与贫穷的生存。本研究旨在解读的作用不同的肿瘤浸润细胞子集嗯为了识别潜在的未来的免疫治疗治疗的目标。我们选择TCGA-UVM队列作为训练数据集和GSE22138作为测试数据集,挖掘公开可用的数据库。大量的估计使用CIBERSORTx 22免疫细胞类型。然后,确定肿瘤浸润细胞子集的意义,我们建立了一个多单元的类型预后签名,验证测试队列中。创建签名是建立在消极的预后CD8 + T细胞的作用和M0巨噬细胞和中性粒细胞的积极作用。基于创建签名的分数,我们把患者分为低收入和高危人群。kaplan meier,考克斯和ROC分析展示了性能优越的风险评分相比,两组的临床或病理特征。进一步,我们发现与癌症immunoevasion和转移相关的分子途径丰富的高危人群,解释都缺乏足够的免疫监视尽管增加CD8 + T细胞的渗透以及高转移潜能。 Genes associated with tryptophan metabolism (IDO1 and KYNU) and metalloproteinases were among the most differentially expressed between the high- and low-risk groups. Our correlation analyses interpreted in context of published in vitro data strongly suggest the central role of CD8+ T cells in shifting the UM tumor microenvironment towards suppressive and metastasis-promoting. Therefore, we propose further investigations of IDO1 and metalloproteinases as novel targets for immunotherapy in lymphocyte-rich metastatic UM patients. SN - 2314-8861 UR - https://doi.org/10.1155/2021/9920234 DO - 10.1155/2021/9920234 JF - Journal of Immunology Research PB - Hindawi KW - ER -