TY -的A2 - Lu,小杰盟——刘Guokun AU - Du,玄盟-肖,李盟——曾清盟——刘QianLing PY - 2021 DA - 2021/10/15 TI -激活FGD5-AS1促进宫颈癌的进展通过调节BST2抑制巨噬细胞M1极化SP - 5857214六世- 2021 AB -越来越多的证据阐明lncRNAs在各种肿瘤的生物功能。FGD5反义RNA 1 (FGD5-AS1)被确定为一个重要的肿瘤恶性肿瘤的监管机构。到目前为止,FGD5-AS1在宫颈癌的详细功能和其潜在的分子机制仍然被知晓。骨髓基质细胞抗原2 (BST2)免疫反应中扮演关键的角色,以及角色的BST2宫颈癌是目前探索。FGD5-AS1和BST2检测宫颈癌细胞的存在。FGD5-AS1和BST2表达显著调节在宫颈癌细胞。然后,减少FGD5-AS1大大体外抑制宫颈癌细胞生长。此外,FGD5-AS1沉默压抑BST2表达和M2巨噬细胞极化。从力学上看,我们证实FGD5-AS1擦掉mir - 129 - 5 - p在BST2减少抑制。此外,缺乏BST2抑郁宫颈癌细胞生长,诱导细胞凋亡。 Loss of BST2 induced M1 macrophage polarization while blocking M2 macrophage polarization. For another, we demonstrated that FGD5-AS1-triggered M2 macrophage polarization was remarkably reversed by miR-129-5p via suppressing BST2. In conclusion, FGD5-AS1 induced M2 macrophage polarization via sponging miR-129-5p and modulating BST2, thus contributing to cervical cancer development. Our findings revealed FGD5-AS1/miR-129-5p/BST2 as a new potential target for cervical cancer. SN - 2314-8861 UR - https://doi.org/10.1155/2021/5857214 DO - 10.1155/2021/5857214 JF - Journal of Immunology Research PB - Hindawi KW - ER -