TY - JOUR A2 - Sautto，朱塞佩A. AU - Ailincai，丹妮拉AU - Dorobanţu，亚历山德拉玛丽亚AU - 迪马，波格丹AU - Irimiciuc，斯特凡·安德烈AU - Lupaşcu，克里斯蒂安AU - AGOP，马里切尔AU - Olguta，奥尔赞PY - 2020DA - 2020年5月31日TI - 聚（乙烯醇硼酸）-Diclofenac钠盐给药系统：实验与理论研究SP - 3124304 VL - 2020 AB - 本文的主要目标是模拟由药物释放多重分形理论模型，以评估药物释放机制一种有价值的方法。要做到这一点，通过混合从90/10至70/30的聚（乙烯醇硼酸）（PVAB）和双氯芬酸（DCF）钠盐的药物以不同的质量比，以获得药物递送系统与制备药物递送膜不同的释放速率。这三个系统的不同的药物含量通过能量色散光谱（EDAX）分析证实，并通过扫描电子显微镜（SEM），原子力显微镜（AFM）在封装的特殊性进行了调查，和偏光显微镜（POM）的技术。所述PVAB矩阵的对锚点的DCF通过傅立叶评估的能力变换红外（FTIR）光谱。该 体外从制剂中的双氯芬酸钠盐的释放在仿生条件进行了研究（ pH值 = 7.4 and 37°C) by UV-Vis spectroscopy, measuring the absorbance of the drug at 275 nm and fitting the results on a previously drawn calibration curve. An estimation of the drug release kinetics was performed by fitting three traditional mathematical models on experimental release data. Further, the drug delivery was simulated by the fractal theory of motion, in which the release dynamics of the polymer-drug complex system is described through various Riccati-type “regimes.” To explain such dynamics involved multifractal self-modulation in the form of period doubling, quasiperiodicity, intermittency, etc., as well as multifractal self-modulation of network type. Standard release dynamics were explained by multifractal behaviors of temporary kink type. The good correlation between the traditional mathematical models and the new proposed theoretical model demonstrated the validity of the multifractal model for the investigation of the drug release. SN - 2314-8861 UR - https://doi.org/10.1155/2020/3124304 DO - 10.1155/2020/3124304 JF - Journal of Immunology Research PB - Hindawi KW - ER -