TY - JOUR A2 - Liu, jiamin AU - Liu, Mingfa AU - Xu, Zhennan AU - Du, Zepeng AU - Wu, Bingli AU - Jin, Tao AU - Xu, Ke AU - Xu, Liyan AU - Li, Enmin AU - Xu，SP - 1278081 VL - 2017 AB -胶质瘤是中枢神经系统中最常见的恶性肿瘤。本研究旨在探讨胶质瘤发生的可能机制，并鉴定其基因特征。对胶质瘤基因表达谱GSE4290进行差异表达基因(DEGs)分析。富集途径采用基因本体论(GO)和京都基因与基因组百科全书(KEGG)分析。通过构建蛋白质相互作用(PPI)网络来寻找枢纽基因。进行生存分析，筛选和验证关键基因。在本研究中，共鉴定了775个下调的DEGs。GO分析表明，DEGs富集于细胞蛋白修饰、细胞通讯调控和信号传导调控。KEGG分析表明，DEGs在MAPK信号通路、胞吞作用、催产素信号通路和钙信号通路中富集。 PPI network and module analysis found 12 hub genes, which were enriched in synaptic vesicle cycling rheumatoid arthritis and collecting duct acid secretion. The four key genes CDK17, GNA13, PHF21A, and MTHFD2 were identified in both generation (GSE4412) and validation (GSE4271) dataset, respectively. Regression analysis showed that CDK13, PHF21A, and MTHFD2 were independent predictors. The results suggested that CDK17, GNA13, PHF21A, and MTHFD2 might play important roles and potentially be valuable in the prognosis and treatment of glioma. SN - 2314-8861 UR - https://doi.org/10.1155/2017/1278081 DO - 10.1155/2017/1278081 JF - Journal of Immunology Research PB - Hindawi KW - ER -