TY - JOUR A2 - BenMohamed, Lbachir AU - Bryant-Hudson, Katie M. AU - Carr, Daniel J. J. PY - 2012 DA - 2012/02/28 TI - PD-L1-Expressing Dendritic Cells Contribute to Viral Resistance during Acute HSV-1 Infection SP - 924619 VL - 2012 AB - The inhibitory receptor, Programmed Death 1 (PD-1), and its ligands (PD-L1/PD-L2) are thought to play a role in immune surveillance during chronic viral infection. The contribution of the receptor/ligand pair during an acute infection is less understood. To determine the role of PD-L1 and PD-L2 during acute ocular herpes simplex virus type 1 (HSV-1) infection, HSV-1-infected mice administered neutralizing antibody to PD-L1 or PD-L2 were assessed for viral burden and host cellular immune responses. Virus titers were elevated in cornea and trigeminal ganglia (TG) of anti-PD-L1-treated mice which corresponded with a reduced number of CD80-expressing dendritic cells, PD-L1⁺树突细胞和HSV-1特异性CD8⁺排水（下颌）淋巴结（MLN）内的T细胞。相比之下，抗PD-L2处理对病毒复制或MLN群体的变化没有影响。值得注意的是，来自抗PD-L1处理的小鼠的CD11C富含MLN细胞的分析显示出功能性损害。这些研究表明，在急性HSV-1感染期间，表达PD-L1表达的树突状细胞对于抗病毒防御是重要的。SN - 2314-8861 UR - https://doi.org/10.1155/2012/924619 Do - 10.1155 / 2012/924619 JF - 临床和发育免疫学PB - Hindwi Publishing Corporation KW - ER -