TY -的A2 Campesi Ilaria AU -朱,宁非盟-黄,Bingwu盟——朱,品鉴AU - Wang Yi PY - 2021 DA - 2021/12/07 TI -潜在机制对糖尿病心肌病Triptolide基于网络药理学分析和分子对接SP - 9944589六世- 2021 AB -心力衰竭的发病率显著增加患者的糖尿病心肌病(DCM)。triptolide在扩张型心肌病的治疗效果已被报道,但潜在的机制还有待阐明。本研究旨在调查的潜在目标triptolide作为DCM使用网络药理学的治疗策略的方法。Triptolide和它的目标是确定的中药药理学的数据库系统。DCM-associated蛋白质目标被确定使用比较toxicogenomics数据库和GeneCards数据库。的网络triptolide-target基因和基因由Cytoscape DCM-associated目标。共同目标和丰富通路基因本体论(去)和《京都议定书》确定的基因和基因组的百科全书(KEGG)通路富集分析。GeneMANIA基因基因相互作用网络分析的数据库。由Cytoscape drug-target-pathway网络。六个候选人蛋白质目标被确定在triptolide目标网络和DCM-associated网络:STAT3, VEGFA,安全系数,TNF, TP53, TGFB1。 The gene-gene interaction based on the targets of triptolide in DCM revealed the interaction of these targets. Additionally, five key targets that were linked to more than three genes were determined as crucial genes. The GO analysis identified 10 biological processes, 2 cellular components, and 10 molecular functions. The KEGG analysis identified 10 signaling pathways. The docking analysis showed that triptolide fits in the binding pockets of all six candidate targets. In conclusion, the present study explored the potential targets and signaling pathways of triptolide as a treatment for DCM. These results illustrate the mechanism of action of triptolide as an anti-DCM agent and contribute to a better understanding of triptolide as a transcriptional regulator of cytokine mRNA expression. SN - 2314-6745 UR - https://doi.org/10.1155/2021/9944589 DO - 10.1155/2021/9944589 JF - Journal of Diabetes Research PB - Hindawi KW - ER -