TY -的A2 Nunemaker克雷格·s . AU - Pierzynowska Kateryna盟——Oredsson Stina盟——Pierzynowski Stefan PY - 2020 DA - 2020/11/18 TI - Amylase-Dependent调节葡萄糖代谢和胰岛素/胰高糖素分泌的功能障碍在糖尿病猪体外实验模型和大鼠胰腺β细胞,BRIN-BD11 SP - 2148740六世- 2020 AB -当前的研究旨在强调血胰淀粉酶的作用在调节葡萄糖体内平衡和胰岛素分泌在猪模型的链脲霉素(STZ)诱导糖尿病大鼠胰腺β细胞线,BRIN-BD11。血糖、血浆胰岛素和胰高血糖素水平测定十二指肠后葡萄糖耐量试验(IDGTT),与STZ-induced四猪2型糖尿病(T2D猪)和四个猪STZ-induced 1型糖尿病(内转至猪)。四个完整的猪作为对照组。淀粉酶的影响在两个急性和慢性补充胰岛素分泌决心BRIN-BD11细胞系。淀粉酶注入没有影响葡萄糖利用率曲线或胰高血糖素水平在健康的猪。然而,显著降低的胰岛素释放观察健康猪淀粉酶处理。T2D猪,葡萄糖利用率曲线在淀粉酶的存在明显降低,而胰岛素响应曲线保持不变。淀粉酶也显著增加胰高血糖素释放在IDGTT T2D和近年来的猪,与2 - 4倍。淀粉酶并不影响葡萄糖利用率曲线内转至猪。补充淀粉酶显著减少急性和慢性BRIN-BD11的胰岛素分泌细胞。 These data confirm our previous observations and demonstrate the participation of pancreatic amylase in glucose absorption/utilization. Moreover, the present study clearly highlights the direct impact of pancreatic blood amylase on insulin secretion from pancreatic beta-cells and its interactions with insulin and glucagon secretion in a porcine model. SN - 2314-6745 UR - https://doi.org/10.1155/2020/2148740 DO - 10.1155/2020/2148740 JF - Journal of Diabetes Research PB - Hindawi KW - ER -