TY -的A2 Georgiopoulou Vasiliki盟——Dozio Elena盟——Vianello Elena AU - Briganti,西尔维亚AU -拉蒙特,约翰•AU - Tacchini罗伦萨盟-施密茨,Gerd AU -科西Romanelli Massimiliano马可PY - 2016 DA - 2015/12/14 TI -受体的表达在心外膜脂肪:先进的糖化结束产品链接与当地组织厚度和胰岛素抵抗在冠状动脉疾病SP - 2327341六世- 2016 AB -受体表达增加先进的糖化终端产品(愤怒)在脂肪组织与炎症有关,脂肪细胞肥大,受损的胰岛素信号。心外膜脂肪组织(吃),心肌周边的内脏脂肪,可能参与了发病/冠状动脉疾病(CAD)的进展。到目前为止,这个角色吃没有了太多的愤怒。我们检查是否吃与吃的愤怒表达肥胖症和代谢障碍通常发现在CAD患者。吃从33接受心脏手术的患者获得的样本。吃的表达愤怒,GLUT4、adiponenctin GLO1, HMGB1,地,MyD88被微阵列分析。吃厚度由超声心动图量化。人体测量和临床参数。BMI、HOMA-IR和圈指数计算。随着愤怒表达吃我们观察到增加吃厚度,GLUT4的表达减少,脂联素,GLO1, HMGB1的海拔,地,MyD88。 There were significant correlations between RAGE and EAT thickness and between RAGE and the genes. LAP was higher in patients with increased RAGE expression. Our data suggest that in CAD patients RAGE may be involved in promoting EAT adiposity and metabolic dysfunction, such as impaired insulin signaling. SN - 2314-6745 UR - https://doi.org/10.1155/2016/2327341 DO - 10.1155/2016/2327341 JF - Journal of Diabetes Research PB - Hindawi Publishing Corporation KW - ER -