TY - A2的山田Takahisa盟——Sasase Tomohiko盟——太武盟——Masuyama佐藤AU -提价Norihide盟——Kakehashi Akihiro AU -筱原Masami PY - 2013 DA - 2013/02/25 TI -自发糖尿病鸟居鼠:Nonobese 2型糖尿病的动物模型有严重糖尿病并发症SP - 976209六世- 2013 AB -自发糖尿病鸟居(SDT)大鼠的近交品系Sprague-Dawley鼠和最近的Nonobese模型建立2型糖尿病(T2D)。男性SDT老鼠显示高血浆葡萄糖水平(超过700 mg / dL) 20周。男性SDT老鼠显示胰岛组织病理学,包括出血与成纤维细胞胰岛细胞和炎性细胞浸润。糖尿病的发病之前,葡萄糖耐受不良和hypoinsulinemia也观察到。由于慢性严重的高血糖,SDT老鼠发展深刻的并发症。在眼睛、视网膜病变、白内障和新生血管性青光眼。特别是增生性视网膜病变,造成视网膜新生血管性这个模型的血管是一个独特的特征。肾脏系膜增生和结节状病变。周围神经病变如神经传导速度和减少热痛觉减退和自主神经病变如糖尿病腹泻和排尿功能障碍的报告。骨质疏松症是另一个并发症表现为SDT老鼠。 Decreased bone density and low-turnover bone lesions are observed. Taking advantage of these features, SDT rat has been used for evaluating antidiabetic drugs and drugs/gene therapy for diabetic complications. In conclusion, the SDT rat is potentially a useful T2D model for studies on pathogenesis and treatment of diabetic complications in humans. SN - 2314-6745 UR - https://doi.org/10.1155/2013/976209 DO - 10.1155/2013/976209 JF - Journal of Diabetes Research PB - Hindawi Publishing Corporation KW - ER -