瘦素及其与肥胖和胰岛素的关系在月/ N-corpulent老鼠,II型糖尿病的典范

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自发性高血压/ NIH-corpulent(月/ N-cp)鼠是一种遗传动物模型展览肥胖、代谢特性的高胰岛素血症,高血糖和高脂血症,II型糖尿病和轻度高血压的特征。确定瘦素的作用,蛋白质的产物ob肥胖和糖尿病发展的基因,在这个模型中,我们测量稳态循环水平的瘦素在肥胖和苗条萎缩/ N-cp老鼠和检查血浆瘦素水平和代谢变量之间的关系建立阶段的肥胖在这些动物。意思是空腹血浆瘦素浓度高出8倍肥胖比瘦老鼠(p < 0.01)。这是与倍高度相关血浆胰岛素在肥胖组。空腹血浆葡萄糖水平,胆固醇和甘油三酯在肥胖老鼠都显著高于在精益控制。斯皮尔曼相关分析血浆瘦素浓度之间呈显著正相关,体重在动物(r = 0.73, p < 0.01)。同样,血浆胰岛素浓度在所有动物与BW显著相关(r = 0.54, p < 0.05)。也有显著的积极。相关性血浆瘦素和血浆胰岛素在整个集团(r = 0.70, p < 0.01)。然而,这种关系是重要的只有瘦老鼠而不是肥胖老鼠(r = 0.59, p < 0.05瘦老鼠,r = 0.23, p = NS,肥胖老鼠)。血浆瘦素还将积极与空腹血糖(r = 0.75, p < 0.05),总胆固醇(r = 0.63, p < 0.05),甘油三酯(r = 0.67, p < 0.05)。 The marked elevation of plasma leptin in obese SHR/N-cp rats suggests that obesity in this animal model is related to up-regulation of the ob gene. Circulating leptin appears to be one of the best biological markers of obesity and that hyperleptinemia is closely associated with several metabolic risk factors related to insulin resistance in the diabesity syndrome.

糖尿病研究期刊》的研究

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