TY -的A2 -洛伦西尼,Antonello盟——Kamalashiran Chuntida盟——Pattaraarchachai AU - Muengtaweepongsa淳弥,Sombat PY - 2018 DA - 2018/06/04 TI -紫苏子油的可行性和安全性作为额外的抗氧化治疗轻度至中度痴呆患者SP - 5302105六世- 2018 AB -痴呆是一种广谱的术语在认知功能退化严重干预日常生活活动。氧化应激中起着重要作用在神经退行性级联,导致痴呆的不可逆转的机制。紫苏子油是从它的种子中提取的,包含一个高的抗氧化物质,如ω- 3脂肪酸来源。以其突出的抗氧化性质,紫苏子油显示神经保护效应对痴呆的临床前研究。我们的目标是证明紫苏子油的可行性和安全性作为额外的抗氧化治疗患者的痴呆。这单中心,双盲,安慰剂对照试验随机239例临床诊断为轻度至中度痴呆细微精神状态检查根据泰国(TMSE) 10 - 23分或泰国蒙特利尔认知评估12至25分。两个胶囊含有500毫克的紫苏子油或同样出现两个胶囊含有500毫克的橄榄油(安慰剂)每天四次被添加到传统的标准治疗痴呆的六个月。临床副作用和常规实验室结果在基线和治疗后两组之间的比较。恶心和呕吐是最常见的临床副作用(3%)发现同样在两组。三个病人安慰剂组过早地停止了药物治疗,而只有一个病人在治疗组早戒烟药物。 However, about 5% of patients in both groups could not comply with the regimen of the treatment. The routine laboratory results, including complete blood counts, kidney function tests, and liver function panels, at baseline and after treatment, were not significantly different in both groups. In conclusion, perilla seed oil was feasible and safe to add on with standard treatment in patients with mild to moderate dementia. Further study is needed to confirm its benefit to use as additional antioxidative therapy in patients with dementia. SN - 2090-2204 UR - https://doi.org/10.1155/2018/5302105 DO - 10.1155/2018/5302105 JF - Journal of Aging Research PB - Hindawi KW - ER -