tyjour A2 - Ronco, Claudio AU - Lazzeri, Chiara AU - Valente, Serafina AU - Tarquini, Roberto AU - Gensini，吉安弗朗哥PY - 2011 DA - 2011/02/07 TI - Cardiorenal综合症引起的心力衰竭与射血分数保留SP - 634903六世- 2011 AB——因为Cardiorenal障碍通常是继发于多种因素协同作用(不仅减少心输出量)在本文我们要关注之间的相互关系heart failure with normal ejection fraction and the development of cardiorenal syndrome. The coexistence of renal impairment in heart failure with preserved ejection fraction (CRS type 2 and 4) is common especially in older females with hypertension and/or diabetes. It can be hypothesized that the incidence of this disease association is growing, while clinical trials enrolling these patients are still lacking. The main mechanisms thought to be involved in the pathophysiology of this condition are represented by the increase of intra-abdominal and central venous pressure and the activation of the renin-angiotensin system. Differently from CRS in heart failure with reduced ejection fraction, the involvement of the kidney may be under-diagnosed in patients with heart failure and preserved ejection fraction and the optimal therapeutic strategy in this condition, though challenging, is far to be completely elucidated. Further studies are needed to assess the best therapeutic regimen in patients with renal dysfunction (and worsening) and heart failure and preserved ejection fraction. SN - 2090-214X UR - https://doi.org/10.4061/2011/634903 DO - 10.4061/2011/634903 JF - International Journal of Nephrology PB - SAGE-Hindawi Access to Research KW - ER -