TY - JOUR A2 - Bavbek, Nuket AU - AlAmeel, Turki AU - West，迈克尔PY - 2011 DA - 2011/06/01 TI -氨甲环酸治疗多囊肾疾病危及生命的血尿的SP - 203579六世- 2011 AB -一个41岁的女人与常染色体显性遗传多囊肾疾病慢性肾病四级。她给了10天产后一个为期4天的历史严重血尿,左腰痛,贫血，血红蛋白62 g/L。CT扫描显示肾脏巨大肿大及多发囊肿;双侧数个囊肿呈高度衰减，与出血相符。尽管采取了强化的保守措施(包括维生素K1、4单位血浆、输血10单位红细胞、达波生素和DDAVP)，血尿仍持续数日。口服氨甲环酸1000 mg，口服1天。在氨甲环酸治疗结束后，血尿在24小时内停止，且未复发。在接下来的4年里，有3例住院治疗，每例都有严重的肉眼血尿，需要为急性贫血输血。进一步用氨甲环酸治疗血尿反应良好。 Tranexamic acid produces antifibrinolytic effects via complex interactions with plasminogen, displacing plasminogen from the fibrin surface. Chronic renal impairment is considered a relative contraindication to use of tranexamic acid due to reports of ureteric clots and acute renal failure from cortical necrosis. We conclude that tranexamic acid can be used safely in some patients with CKD and polycystic kidney disease to treat severe hematuria. SN - 2090-214X UR - https://doi.org/10.4061/2011/203579 DO - 10.4061/2011/203579 JF - International Journal of Nephrology PB - SAGE-Hindawi Access to Research KW - ER -