TY - JOUR A2 - Slomiany,B.L.AU - Knaut,卡罗琳AU - BONFANTI梅斯基塔,罗莱AU - Dourado,维克多祖尼加AU - 德戈多伊,伊尔玛AU - 坦妮,苏珊娜E. PY - 2020 DA - 2020年4月28日TI - 炎症标志物评估患者经历短期有氧运动住院期间因COPD SP急性加重 - 6492720 VL - 2020 AB -
介绍。急性加重是慢性阻塞性肺疾病(COPD),预后更差的一个重要因素。它促进炎症过程的增加而恶化的生活,肺功能和肌肉无力的质量。据认为,体育锻炼不增加炎症过程中加重休息进行全身表现的恶性循环。
目的。为了评估炎症标志物住院期间短期的有氧锻炼身体的影响。
患者与方法。26 patients were evaluated (69.2% female, FEV 137.5 ± 12.9%, and age 68.4 ± 11.6 years) 24 hours after hospitalization for smoking history, Charlson index, quality of life, systemic inflammatory markers, and body composition. After 48 hours of hospitalization, all patients underwent a 6-minute walk test (6MWT) and a new spirometry test, and BODE index was calculated. After 72 hours of hospitalization, patients in the intervention group underwent aerobic exercise on a treadmill for 15 minutes twice daily; before and after the aerobic exercise, blood samples were collected for evaluation of inflammatory markers. Finally, a month after hospital discharge, all patients were reevaluated according to systemic inflammatory markers, quality of life, body composition, spirometry, 6MWT, and BODE index.
结果。两组患者在疾病和一般特征的严重程度没有差异。干预组并未出现在有氧运动后的炎症过程恶化:TNF-
α从1.19(0 99-1.71)至1.21(0.77-1.53)(
p
=
0.58
),IL-6从2.41(2.02-0.58)2.66(1.69-0.48)(
p
=
0.21
),以及CRP从3.88(2.26-8.04)4.07(2.65-13.3)(
p
=
0.56
)。有所述IL-6标记和6MWT之间存在负相关性;也就是说,随着炎症水平的降低,有在出院后一个月运动能力的提高。
结论。目前的研究表明,在患者的加剧慢性阻塞性肺病住院期间发起的有氧运动并没有恶化炎症过程。SN - 2090-8040 UR - https://doi.org/10.1155/2020/6492720 DO - 10.1155 /六百四十九万二千七百二十○分之二千零二十零JF - 国际期刊炎症PB的 - Hindawi出版KW - ER -