日A2 - Li, AU - Dzhalilova, Dzhuliia Sh. AU - Kosyreva, Anna M. AU - Diatroptov, Mikhail E. AU - Zolotova, Natalia A. AU - Tsvetkov, Ivan S. AU - Mkhitarov, Vladimir A. AU - Makarova, Olga V. AU - Khochanskiy，德米特里·n . PY - 2019 DA - 2019/04/01 TI -胸腺和脾脏的形态特征和在外周血淋巴细胞的分组人口构成系统性炎症反应在雄性老鼠不同的抗缺氧SP - 7584685六世- 2019 AB -模型的系统性炎症反应(SIRS),由脂多糖(LPS),研究了不同耐缺氧大鼠胸腺、脾脏的形态和功能变化以及外周血淋巴细胞亚群组成。结果表明，耐缺氧大鼠LPS给药3h后血清内毒素水平比对照组高64倍，而耐缺氧大鼠6h后血清内毒素水平仅高出8倍。LPS注射24小时后，只有易耐缺氧大鼠血清c反应蛋白水平升高。耐低氧和耐低氧动物注射LPS后淋巴器官形态学变化的动力学存在差异。LPS给药3小时后，耐缺氧大鼠的胸腺、脾脏和外周血淋巴细胞亚群组成均无变化。6小时后，只有b淋巴细胞减少，细胞毒性t淋巴细胞和NK细胞增加。LPS注射1天后，耐缺氧大鼠脾脏的PALS出现破坏。3小时后注射LPS susceptible-to-hypoxia动物的反应性淋巴器官的变化:降低胸腺皮质的,缩小脾脏淋巴滤泡的边缘区域,扩大他们的生发中心,和一个绝对数量的减少细胞毒性t淋巴球,NK细胞和淋巴细胞。 After 24 hours of LPS injection the tolerant-to-hypoxia animals had a greater absolute number of T-lymphocytes and NK cells in comparison with the susceptible rats. Thus, in animals with different resistance to hypoxia the LPS-induced SIRS is characterized by different dynamics of morphological and functional changes of the thymus and spleen. The obtained data will serve as a basis for the development of new individual approaches to the prevention and treatment of infectious and inflammatory diseases. SN - 2090-8040 UR - https://doi.org/10.1155/2019/7584685 DO - 10.1155/2019/7584685 JF - International Journal of Inflammation PB - Hindawi KW - ER -