TY - JOUR A2 - Slomiany, B. L. AU - Khondkaryan, Lusine AU - Margaryan, Sona AU - Poghosyan, David AU - Manukyan, Gayane PY - 2018 DA - 2018/01/14 TI - Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus SP - 2157434 VL - 2018 AB - Type 2 diabetes mellitus (T2DM) is a severe health problem worldwide, reaching epidemic levels. High susceptibility to infections of T2DM patients indicates dysregulated immune responses to pathogens. However, innate immune responses, including monocyte functions, in T2DM are poorly investigated. Therefore, in this study we aimed to assess lipopolysaccharide- (LPS-) induced immune responses of circulating monocytes from T2DM patients. The results showed that monocytes from T2DM were hyporesponsive to LPS challenge as reflected by significantly suppressed secretion of TNF α（ P. < 0.01 ）和CD11b的表达（ P. < 0.001 ）和tlr4（ P. < 0.001 ）与来自健康受试者的单核细胞中的那些相比。此外，糖尿病和健康上清液中的LPS诱导的IL-10水平相似，而CD163的表达水平被发现在来自T2DM的单核细胞上下调（ P. < 0.001 ）表明单核细胞将其表型切换到抗炎的障碍能力。我们的结果表明，T2DM中单核细胞的损害功能可能在这些患者中至少部分地解释，至少部分地，感染的感染率高。SN - 2090-8040 UR - https://doi.org/10.1155/2018/2157434 Do - 10.1155 / 2018/2157434 JF - 国际炎症PB - Hindawi KW - ER -