TY - Jour A2 - Cavaillon，Jean-Marc Au - Coope，Andressa Au - Pascoal，LíviaBitencourtAu - Da Silva，Francesca Aparecida Ramos Au - Botezelli，JoséIegoAu - Ayrizono，Maria de Lourdes Setsuko Au - Milanski，Marciane Au -Camargo，Michel Gardere Au - Planell，NúriaAu - Portoveo，Mariana Au - Dias，Cilene Bicca Au - Fagundes，JoãoJoséAu - Leal，Raquel Franco Py - 2017 Da - 2017/04/09 Ti - 转录和分子途径激活Mesenteric Adipose Tissue and Intestinal Mucosa of Crohn’s Disease Patients SP - 7646859 VL - 2017 AB - Crohn’s disease (CD) is a chronic inflammatory disorder, characterized by cytokine imbalance and transcription signaling pathways activation. In addition, the increase of mesenteric adipose tissue (MAT) near the affected intestinal area is a hallmark of CD. Therefore, we evaluated the transcription signaling pathways and cytokines expression in intestinal mucosa and MAT of active CD patients. Ten patients with ileocecal CD and eight with noninflammatory diseases were studied. The biopsies of intestinal mucosa and MAT were snap-frozen and protein expression was determined by immunoblotting. RNA levels were measured by qPCR. The pIkB/IkB ratio and TNF α与对照相比，CD的肠粘膜水平明显高。然而，Dat1表达在CD和对照的肠粘膜之间类似。考虑到垫子，PIKB / IKB比率显着降低，与对照相比，CD抗炎细胞因子IL10显着高。最后，与对照相比，CD垫中Pstat1的蛋白质含量较高。这些发现增强了临胆粘膜粘膜中促炎NF-KB途径的主要态度。我们首次表明CD患者垫中Stat1途径的激活，这可能有助于了解这种免疫介导的疾病的物理化学病变。SN - 2090-8040 UR - HTTPS://Doi.org/10.1155/2017/7646859 Do - 10.1155/2017/7646859 JF - 国际炎症PB - Hindawi KW - ER -