TY - JOUR A2 - Giagulli, Vito Angelo AU - Liu, Zhaoxiang AU - Mao, Jiangfeng AU - Xu, Hongli AU - Wang, Xi AU - Huang, Bingkun AU - Zheng, Junjie AU - Nie, Min AU - Zhang, Hongbing AU-Wu，Xueyan PY -2019 DA -2019/12/18 Ti-促性腺激素诱导的CHH患者患者的精子发生SP -6743489 VL -2019 AB- 2019 AB-先天性低神经性低位核（CHH）患者通常患有Spsportor Chistoration史，而较差专注于这一人群的研究很少。这项研究回顾性地评估了促性腺激素诱导的CHH患者的精子发生结果（ n = 40). One hundred and eighty-three CHH patients without cryptorchidism were served as control. All patients received combined gonadotropins therapy (HCG and HMG) and were followed up for at least 6 months. The median follow-up period was 24 (15, 33) months (totally 960 person-months). Sperm (>0/ml) initially appeared in semen at a median of estimated 24 months (95% confidence interval (CI) 17.8–30.2). Twenty (20/40, 50%) patients succeeded in producing sperms, and the average time to produce first sperm was 19 ± 8 months. Five pregnancies were achieved in 9 (5/9, 56%) couples who desired for children. Compared with CHH patients without cryptorchidism ( n = 183), cryptorchid patients had longer median time for sperm appearance in semen (24 months vs. 15 months, p < 0.001 ），精子发生率较低（50％比67％， p = 0.032 ）和较低的平均精子浓度（1.9（0.5，86）百万/毫升与11.1（1.0，25.0）百万/毫升， p = 0.006 ）在上次访问中。总之，CHH患有隐齿术的患者需要更长的时间促性腺激素诱导的精子发生。成功的速率和精子浓度低于没有隐齿的患者。SN -1687-8337 UR- https：//doi.org/10.1155/2019/6743489做 - 10.1155/2019/2019/6743489 JF-国际内分泌杂志PB- Hindawi KW -er -er- er- er-