TY -的A2 -齐勒尔称,Volker盟——Matuszczak Ewa盟——Hermanowicz亚当AU - Komarowska,玛尔塔非盟- Debek Wojciech PY - 2013 DA - 2013/10/24 TI -在生理和病理上血清抗苗勒氏管激素的男性性腺SP - 128907六世- 2013 AB -抗苗勒氏管激素分泌不成熟的塞尔托利氏细胞(SC)和负责回归缪氏导管的男性胎儿的性别分化过程。抗苗勒氏管激素也参与睾丸发育和功能。抗苗勒氏管激素是在出生后第一天的最低水平,但增加后第一周,可能反映出活跃的SC扩散。抗苗勒氏管激素上升迅速集中在第一个月的男孩,在大约6个月的年龄达到峰值水平,然后缓慢下降在儿童时期,在青春期降至较低水平。基底和FSH-stimulated抗苗勒氏管激素的水平,可能成为一个有用的预测标志的精子发生的反应促性腺的治疗年轻患者hypogonadotropic性腺机能减退。青春期后,抗苗勒氏管激素释放优先的顶杆SC细精管的内腔,导致更高的精浆的浓度比血清。抗苗勒氏管激素生产和缺陷不敏感,抗苗勒氏管激素由于受体缺陷导致持久米勒管综合症。可测量的值在一个男孩的抗苗勒氏管激素,双边隐睾症是未降到阴囊的睾丸的预测,而检测不到值无睾或卵巢的暗示,将女孩的情况与女性假两性畸形和纯粹的性腺的发育不全。低血清抗苗勒氏管激素浓度与隐睾原本健康的男孩,他们与同龄同行相比,口气中带着明显的睾丸已报告。青春期前的精索静脉曲张患者的抗苗勒氏管激素水平高于控制。 This altered serum profile of AMH in boys with varicoceles may indicate an early abnormality in the regulation of the seminiferous epithelial function. Serum AMH is known to be valuable in assessing gonadal function. As compared to testing involving the administration of human chorionic gonadotropin, the measurement of AMH is more sensitive and equally specific. Measurement of AMH is very useful in young children, because serum gonadotropin concentrations in those who are agonadal are nondiagnostic in midchildhood and serum testosterone concentrations may fail to increase with provocative testing in children with abdominal testes. SN - 1687-8337 UR - https://doi.org/10.1155/2013/128907 DO - 10.1155/2013/128907 JF - International Journal of Endocrinology PB - Hindawi Publishing Corporation KW - ER -