TY - JOUR A2 - Hendriks, Wiljan J. A. J. AU - Togher, Katie L. AU - Kenny, Louise C. AU - O’Keeffe, Gerard W. PY - 2017 DA - 2017/02/21 TI - Class-Specific Histone Deacetylase Inhibitors Promote 11-Beta Hydroxysteroid Dehydrogenase Type 2 Expression in JEG-3 Cells SP - 6169310 VL - 2017 AB - Exposure to maternal cortisol plays a crucial role in fetal organogenesis. However, fetal overexposure to cortisol has been linked to a range of short- and long-term adverse outcomes. Normally, this is prevented by the expression of an enzyme in the placenta called 11-beta hydroxysteroid dehydrogenase type 2 (11 β-HSD2）将活性皮质醇转化为其无活性的代谢物皮质酮。胎盘11. β已知-HSD2在许多不良妊娠并发症中，可能通过表观遗传机制来降低。结果，已经检查了许多泛HDAC抑制剂，以便他们促进11的能力 β-hsd2表达。然而，如果泛HDAC抑制的影响是一种普遍现象，或者如果效果依赖于特定类HDAC，则不知道。在这里，我们检查了泛级HDAC抑制剂的能力来调节11 β-HSD2在JEG3细胞中的表达式。我们发现持续的泛，I类或IIA类HDAC抑制促进了11 β-HSD2表达和预防皮质醇或白细胞介素-1 β- 引起的表达减少。这些结果表明，靶向特定类别的HDAC可以推广11 β-HSD2在JEG3细胞中的表达式。这增加了越来越多的证据，表明HDAC可能对维持正常的胎儿发育至关重要。SN - 1687-8876 UR - https://doi.org/10.1155/2017/6169310 Do - 10.1155 / 2017/6169310 JF - 国际细胞生物学杂志PB - Hindawi KW - ER -