TY - JOUR A2 - Stein, Gary S. AU - Somjen, D. AU - Mirsky, N. AU - Tamir, S. AU - Vaya, J. AU - Posner, G. H. AU - Kaye, A. M. PY - 2009 DA - 2009/09/10 TI - The Response of Creatine Kinase Specific Activity in Rat Pituitary to Estrogenic Compounds and Vitamin D Less-Calcemic Analogs SP - 273651 VL - 2009 AB - We examined the response of rat female pituitary at different metabolic stages to treatments with estrogenic compounds and vitamin D analogs. Immature or ovariectomized (Ovx) female rats responded by increased creatine kinase specific activity (CK) to estradiol-17
β
(
E.
2
),Genistein(g),Daidzein(D),生物晶素A(BA),Quecertin(Qu),羧基-g(Cg),羧基(CBA)和雷洛昔芬(RAL)。当RAL与雌激素一起注射时,抑制响应。当每天注射到OVX大鼠4种不同的时间段时,CK增加了CK。用较少钙化维生素D模拟JK 1624预处理
F
2
-2(JKF)或QW 1624
F
2
-2(qw),然后是雌激素注射导致响应增加和敏感性
E.
2
和抑制抑制
E.
2
按Ral。通过喂食也增加了CK
E.
2
或甘草或其组分剂量 - 依赖于未成熟或ovxrats。糖尿病雌性大鼠没有响应增加的剂量
E.
2
。总之,大鼠雌性垂体是雌激素响应器官,旨在考虑对绝经后妇女的HRT的回应,以获得有益和危险的方面。SN - 1687-8876 UR - https://doi.org/10.1155/2009/273651 Do - 10.1155 / 2009/273651 JF - 国际细胞生物学杂志PB - Hindwi Publishing Corporation KW - ER -