TY - JOUR A2 -Chen Wen-Cheng AU - Khongkaew, puthiporn AU - Chaemsawang，Watcharaphong PY - 2021 DA - 2021/05/28 TI -无刺的蜂胶的开发和特征属性的发展固体脂质纳米粒子加载SP - 6662867六世亲脂性的物质- 2021 AB -无刺的蜜蜂是昆虫所普遍培育农民在泰国东部地区授粉他们的果园。无刺蜜蜂养殖的产品包括蜂蜜和蜂胶。本实验的目的是通过比较五种表面活性剂(Brij 721, Cremophor WO 7, Myrj 52, Poloxamer 188和Tween 80)，研究将无刺蜂胶蜡制成固体脂质纳米颗粒(SLN)的可能性。每种表面活性剂有三种浓度:10%、20%和30%。主配方是根据以下因素选择的:物理特性、粒径、ζ电位和捕集。结果表明，20%的Brij 721和Myri 52可用于制备SLN，对维生素E具有良好的保存性能(粒径分别为451.2 nm和416.8 nm， ζ电位分别为- 24.0和- 32.7;EE分别为92.32%和92.00%)。因此，他们进一步发展加入以下低溶解度药物:姜黄素，布洛芬，虾青素。 It is found that a formula using the surfactants Brij 721 and Myrj 52 at 20% have similar drug entrapment. The entrapment study involves curcumin 82%, ibuprofen 40%, and astaxanthin 67%. Moreover, the cytotoxicity test of blank solid lipid nanoparticle found no toxicty in fibroblast cell line (CRL-2522). Therefore, from this study, it is determined that stingless bee propolis wax has the potential to be developed to provide more efficient SLN in the future. SN - 1687-8787 UR - https://doi.org/10.1155/2021/6662867 DO - 10.1155/2021/6662867 JF - International Journal of Biomaterials PB - Hindawi KW - ER -