TY - JOUR A2 - Galli, Carlo AU - Budiatin, Aniek S. AU - Gani, Maria A. AU - Samirah, AU - Ardianto, Chrismawan AU - Raharjanti, Aulia M. AU - Septiani, Indah AU - Putri, Ni Putu K. P. AU - Khotib, Junaidi PY - 2021 DA - 2021/05/05 TI - Bovine Hydroxyapatite-Based Bone Scaffold with Gentamicin Accelerates Vascularization and Remodeling of Bone Defect SP - 5560891 VL - 2021 AB - Osteomyelitis is an infectious disease which is also a major complication of bone defects. This study aims to determine the effect of bovine hydroxyapatite-gelatin-based bone implants with gentamicin as an antibiotic (BHA-GEL-GEN implant) on the regeneration of bone defects 体内。BHA-GEL-GEN和BHA-凝胶植入物是通过直接压缩制备的。 体内用Wistar大鼠进行研究。将大鼠分为三组：阴性对照，BHA-植入物和BHA-凝胶植入物。所使用的缺陷模型是毛刺孔缺陷模型，直径为2.2 mm和2毫米深。在2,7,14和28天后，处死大鼠。使用X射线射线照相进行骨完整性。使用血红素和曙红（He）染色和免疫组化技术进行放射学检查，具有抗血管内皮生长因子（VEGF）和抗碱性磷酸酶（ALP）抗体。基于射线照相，植入基团在缺陷面积中加速了骨生长。来自他染色的半定量数据表明，植入基团在缺陷面积中加速了骨壳，成骨细胞和骨细胞的迁移。免疫反应评分表明，与另外两组相比，BHA-GEL-GEN组具有更高的VEGF表达。三组没有提供ALP表达的显着差异。 In conclusion, the BHA-GEL-GEN implant causes accelerated bone defects repair by accelerating tissue vascularity and does not interfere with the bone remodeling process. Therefore, the BHA-GEL-GEN implant is potentially a biomedical material for osteomyelitis therapy. SN - 1687-8787 UR - https://doi.org/10.1155/2021/5560891 DO - 10.1155/2021/5560891 JF - International Journal of Biomaterials PB - Hindawi KW - ER -