TY - JOUR A2 - Zhuang, Tiange AU - Hänni, Mari AU - Leppänen, Olli AU - Smedby, Örjan PY - 2012 DA - 2012/12/19 TI - Postangioplasty Restenosis Followed with Magnetic Resonance Imaging in an Atherosclerotic Rabbit Model SP - 747264 VL - 2012 AB - Rationale and Objectives。Testing a quantitative, noninvasive method to assess postangioplasty vessel wall changes in an animal model. Material and Methods。六个新西兰白兔受到atherosclerotic injury, including cholesterol-enriched diet, deendothelialization, and percutaneous transluminal angioplasty (PTA) in the distal part of abdominal aorta (four weeks after deendothelialization). The animals were examined with a 1.5T MRI scanner at three times as follows: baseline (six weeks after diet start and two days after PTA) and four weeks and 10 weeks after-PTA. Inflow angiosequence (M2DI) and proton-density-weighted sequence (PDW) were performed to examine the aorta with axial slices. To identify the inner and outer vessel wall boundaries, a dynamic contour algorithm (Gradient Vector Flow Snakes) was applied to the images, followed by calculation of the vessel wall dimensions. The results were compared with histopathological analysis. Results。The wall thickness in the lesion was significantly higher than in the control region at 4 and 10 weeks, reflecting induction of experimentally created after-angioplasty lesion. At baseline, no significant difference between the two regions was present. Conclusions。It is possible to follow the development of vessel wall changes after-PTA with MRI in this rabbit model. SN - 1687-4188 UR - https://doi.org/10.1155/2012/747264 DO - 10.1155/2012/747264 JF - International Journal of Biomedical Imaging PB - Hindawi Publishing Corporation KW - ER -