y - JOUR A2 - Ejlertsen, Bent AU - Abdul Aziz, Ahmad Aizat AU - Md Salleh, Md Salzihan AU - Ankathil，文德兰花PY - 2020 DA - 2020/04/01 TI -马来西亚的临床病理及预后特点三阴性乳腺癌患者接受TAC化疗方案SP - 8424365六世- 2020 AB -三阴乳腺癌(TNBC)与侵略性肿瘤表型和肿瘤复发的早期诊断。一般来说，临床病理特征如肿瘤大小、患者确诊时的年龄、肿瘤组织学亚型、分级和分期、淋巴结累及和绝经状态等通常被用于预测疾病进展、复发前景和治疗反应。马来西亚TNBC患者的临床病理特征的预后价值是有限的。因此，本研究旨在研究马来西亚TNBC患者行TAC化疗的无病生存(DFS)和总生存(OS)的临床病理特征之间的关系。76例经免疫组化证实的TNBC患者被招募。收集并记录TNBC患者的临床病理特征。采用Kaplan-Meier、log-rank、Cox比例风险回归模型评估TNBC患者的生存率。在76例TNBC患者中，25例化疗耐药，51例对TAC化疗方案有化疗反应。TNBC患者5年累计DFS和OS分别为63.5%和76.3%。 Multivariate Cox analysis demonstrated that medullary and metaplastic histology subtypes and positive axillary lymph node metastasis were significant prognostic factors associated with relapse with adjusted HR: 5.76, 95% CI: 2.35, 14.08 and adjusted HR: 3.55, 95% CI: 1.44, 8.74, respectively. Moreover, TNBC patients with medullary and metaplastic histology subtypes and positive axillary lymph node metastases had a higher risk to death than patients who had infiltrating ductal carcinoma and negative axillary lymph node metastasis (adjusted HR: 8.30, 95% CI: 2.38, 28.96 and adjusted HR: 6.12, 95% CI: 1.32, 28.42, respectively). Our results demonstrate the potential use of medullary and metaplastic histology subtype and positive axillary lymph node metastasis as a potential biomarker in predicting relapse and survival of the TNBC patients. This warrants further studies on intensification of chemotherapy and also identification and development of targeted therapy to reduce relapses and improve survival of TNBC patients. SN - 2090-3170 UR - https://doi.org/10.1155/2020/8424365 DO - 10.1155/2020/8424365 JF - International Journal of Breast Cancer PB - Hindawi KW - ER -