ty -jour a2 -tonetti,debra A. au -Hanna,Matthew G. au -Bleiweiss,Ira J. au -nayak -nayak,anupma au -jaffer,jaffer,shabnam py -2017 da -2017/01/12 ti-在500多名患者中,具有组织形态学和免疫组织化学的复发评分SP -1257078 VL -2017 AB -ONCOTYPE DX用于确定雌激素受体阳性(ER+)和淋巴结阴性(LN)乳腺癌的患者的复发风险(RR)。RR分为低(0-17),中级(18-30)和高(31),以预测化疗益处。我们的目标是确定组织形态学,免疫组织化学和RR之间的关联。我们回顾性地鉴定了536例ER+和LN-乳腺癌患者,这些患者接受了2006年至2013年的型型测试。肿瘤大小范围从0.2 cm至6.5 cm(平均= 1.3 cm)不等,并且在所有3个类别中都是均匀的。癌如下:导管= 63.2%,小叶= 11.1%,混合= 35.7%。RR与诺丁汉等级相关。增加的RR与PR阳性成反比,但与HER2阳性直接相关。在形态学参数中,肾小管(小叶)形态仅与低中等评分和偏型类型相关,并具有中高分。其他形态(如微毛细血管和粘液)在每个类别中均匀分布。 Carcinomas with comedo intraductal carcinoma were more likely associated with high RR. Forty-four patients with either isolated tumor cells or micrometastases were evenly distributed amongst the 3 RR. While there was only 1 ER discrepancy between our immunohistochemistry (3+ 80%) and Oncotype, up to 8% of PR+ cases (mean = 15%, median = 5%) and 2% of HER2+ cases were undervalued by Oncotype. SN - 2090-3170 UR - https://doi.org/10.1155/2017/1257078 DO - 10.1155/2017/1257078 JF - International Journal of Breast Cancer PB - Hindawi KW - ER -