TY - JOUR A2 - Kahán, Zsuzsanna AU - Asegaonkar, Shilpa Balaji AU - Asegaonkar, Balaji Narayanrao AU - Takalkar, Unmesh Vidyadhar AU - Advani, Suresh AU - Thorat, Anand Pandurang PY - 2015 DA - 2015/11/26来自Old Molecule SP - 145647 VL - 2015 AB -最近，乳腺癌和炎症之间的关联已经成为癌症的第七个标志。慢性炎症是癌症发生和发展的关键因素。炎症通路在乳腺癌的发生中起着重要作用。c反应蛋白(CRP)是一种急性期反应性炎症蛋白，在肿瘤微环境中由白细胞释放细胞因子而在肝细胞中合成。几项流行病学研究评估了CRP与乳腺癌风险之间的关系，但结果不一致。乳腺癌诊断时水平升高表明肿瘤具有侵袭性。CRP也是一个成熟的独立预后标志物。患有慢性炎症的乳腺癌幸存者有复发和代谢紊乱的风险。CRP降低剂配合化疗药物将提高乳腺癌患者的生存率。 Also, it is a risk predictor for subsequent cardiotoxicity in patients receiving chemotherapy. The present review is aimed at elucidating the role of C-reactive protein, as an inflammatory risk marker and prognostic predictor of breast cancer. It also focuses on conflicting views on the role of CRP in breast cancer and its impact on therapeutic interventions. SN - 2090-3170 UR - https://doi.org/10.1155/2015/145647 DO - 10.1155/2015/145647 JF - International Journal of Breast Cancer PB - Hindawi Publishing Corporation KW - ER -