TY - JOUR A2 - Yamamoto, Daigo AU - Williams, Norman R. AU - Pigott, Katharine H. AU - Keshtgar, Mohammed R. S. PY - 2011 DA - 2011/06/01 TI - Intraoperative Radiotherapy in the Treatment of Breast Cancer: A Review of the Evidence SP - 375170 VL - 2011 AB - The surgical treatment of early breast cancer has evolved from the removal of the entire breast and surrounding tissues (mastectomy) to the removal of the tumour together with a margin of healthy tissue (lumpectomy). Adjuvant radiotherapy, however, is still mainly given to the whole breast. Furthermore, external beam radiotherapy is often given several months after initial surgery and requires the patient to attend the radiotherapy centre daily for several weeks. A single fraction of radiotherapy given during surgery directly to the tumour bed (intraoperative radiotherapy) avoids these problems. The rationale and level-1 evidence for the safety and efficacy of the technique are reviewed. SN - 2090-3170 UR - https://doi.org/10.4061/2011/375170 DO - 10.4061/2011/375170 JF - International Journal of Breast Cancer PB - SAGE-Hindawi Access to Research KW - ER -