Ty - Jour A2 - Mielke，Michelle M. Au - Liepelt-Scarfone，Inga Au - Gräber，Susanne Au - Fruhmann Berger，Monika Au - Fesceker，Anne Au - Baysal，Gülsüm - Csoti，Ilona Au - Godau，Jana Au -Gaenslen, Alexandra AU - Huber, Heiko AU - Srulijes, Karin AU - Brockmann, Kathrin AU - Berg, Daniela PY - 2012 DA - 2012/10/18 TI - Cognitive Profiles in Parkinson’s Disease and Their Relation to Dementia: A Data-Driven Approach SP - 910757 VL - 2012 AB - Parkinson’s disease is characterized by a substantial cognitive heterogeneity, which is apparent in different profiles and levels of severity. To date, a distinct clinical profile for patients with a potential risk of developing dementia still has to be identified. We introduce a data-driven approach to detect different cognitive profiles and stages. Comprehensive neuropsychological data sets from a cohort of 121 Parkinson’s disease patients with and without dementia were explored by a factor analysis to characterize different cognitive domains. Based on the factor scores that represent individual performance in each domain, hierarchical cluster analyses determined whether subgroups of Parkinson’s disease patients show varying cognitive profiles. A six-factor solution accounting for 65.2% of total variance fitted best to our data and revealed high internal consistencies (Cronbach’s alpha coefficients > 0.6 ）。群集分析建议两个具有不同认知型材的独立患者群集。它们只有在认知障碍和自我报告的日常生活活动局限性的严重程度中差别不同，但不在电机性能，疾病持续时间或多巴胺能药物中。基于数据驱动方法，确定了潜水员认知型材，在没有痴呆的情况下，在帕金森病中分离了帕金森病中的早期和更先进的认知障碍阶段。重要的是，这些简档与电机进展无关。SN - 2090-8024 UR - https://doi.org/10.1155/2012/910757 Do - 10.1155 / 2012/910757 JF - 国际Alzheimer疾病杂志PB - Hindwi Publishing CorporationKW - ER -